Solitary Plasmacytoma of the Mandible: A Case Report

Plasmacytoma is an abnormal proliferation of monoclonal B-cells, and it can occur in several forms including multiple myeloma, solitary plasmacytoma of the bone, and extramedullary plasmacytoma primary. The solitary plasmacytoma of the bone accounts for about 3-10% of all plasma cell neoplasms, and occurs most often in the vertebrae, whereas the solitary plasmacytoma of the mandible is an extremely rare occurrence. This case report presents a 61-year-old woman with various underlying diseases diagnosed with solitary plasmacytoma of the mandible. This case is very well documented with radiographic imagery, clinical, and histopathological findings.

Plasmacytoma arises in three distinct types including (1) multiple myeloma (MM), a cancer of the bone marrow with a deadly and destructive nature that is the most prevalent plasma cell neoplasm, affects multiple bones in osteolytic foci with abundant plasma cells; ( 2) solitary plasmacytoma of bone (SPB), which develops in soft tissue or the maxillary sinus, and (3) extramedullary primary plasmacytoma (PEMP), which develops in soft tissue or the maxillary sinus [1].
A total of 95 percent of SPB types are most common in adults over the age of 40, with men having a higher prevalence [5].SPB is uncommon in the jaw, accounting for only 4% of all occurrences of plasmacytoma in this region. SPB in the jaw has a poor prognosis; with 50% of cases progressing to MM [5][6].This case report pertains to an older patient who was diagnosed with SPB.
Initial clinical examination indicated a mild, anteroposteriorly extending enlargement on the right mandibular body that was painless on palpation, covered with normal, intact mucosa and had a hard, bony consistency.
On panoramic radiography and cone-beam computed tomography (CBCT) scanning, a single elliptical unilocular mixed radiolucent-radiopaque lesion in the right body of the jaw (3.5cm in length and 2.5cm in height) without a sclerotic rim was observed. The lesion extended antero-posteriorly from the mesial aspect of the right mandibular canine to the right first mandibular region (the patient had only eight natural teeth in the anterior segment of the mandible initially), but no exten- showed a positive reaction in plasmacytoid cells, which confirmed the plasmacytoma diagnosis. The second procedure was an excision, followed by a bone marrow aspiration and a biopsy to rule out multiple myeloma.
The findings indicated cellular marrow with 7% plasma cells. An abdominal ultrasound of the liver, bile ducts, spleen, pancreas, and kidneys was ordered to examine other potentially affected foci. However, all organs were found to be normal, and no involvement was suspected. The test for urinary monoclonal protein was negative as well. After being diagnosed with SPB, the patient was referred to an oncologist and received a

Discussion
An SPB incidence in the jawbones is a rare occurrence. The mandible is involved far more commonly than the maxilla. The angle, ramus, and molar are the most affected mandibular regions [5][6]. SPB also occurred in the posterior jaw of the current patient, and it appears that the posterior mandible and its ramus had a higher rate of involvement due to the presence of more bone marrow spaces. In their analysis of documented instances of SPB, Kanazawa et al. [4] found that the incidence of this lesion is higher in men and that the onset age spans from 34 to 76 years. The median age of patients is 53, nearly ten years younger than the median age of individuals with multiple myeloma. The age and gender of the present patient, a 61-year-old female, did not match those reported by Kanazawa et al. [4]. Nonetheless, two SPB cases reported by Kucukkurt et al. [7] share some similarities with the current case. The instances involved a 67-year-old woman and a 61-yearold woman with SPB in the mandible; both patients complained of pain, and the site of the lesion in both cases was the ramus. Although the cause of SPB is unknown, persistent inflammation, radiation, viral infections, and genetic alterations have been linked to its development [1]. Regarding chronic irritation, Poggio [8] reported a case where the titanium surface of a dental implant may have triggered B-cell growth in the mandibular bone space. The aforementioned patient in this case had multiple systemic diseases, including diabetes and hypertension. Caliskan et al. [9] and Yoon et al. [10] found SPB in the jaws of two patients who had had kidney transplantation. However, establishing an association between these two disorders requires additional data. SPB is characterized by nonspecific symptoms, rendering clinical diagnosis challenging. The most prevalent form of SPB is characterized by a persistent swelling of the jaw accompanied by pain, paresthesia, pathologic bone fractures, and loose teeth [1,4,6]. Additionally, the present patient's symptoms appeared as gingival soreness and swelling. However, Kanazawa et al. [4] have determined that the lesion is more likely to be painless.
SPB should be diagnosed based on clinical signs and symptoms, radiographic manifestations, hematological and histological tests, and the absence of systemic alterations related to MM (such as hypercalcemia and anemia with renal involvement) [1].
Despite the fact that the present patient's radiological signs were a solitary, unilocular radiolucency without a sclerotic rim, incisional surgery and the finding of histological alterations consistent with SPB led to a conclusive diagnosis. SPB diagnosis by radiography alone can be difficult at times. Shah and Sarkar observed a plasmacytoma of the jaw that resembled a large periapical cyst radiographically [11]. Liu and Li emphasized the relevance of CT scans in such patients and indicated that the histological symptoms of SPB lesions were consistent with CT scan results in the SPB cases they analyzed [12].
This patient was treated with a combination of excisional surgery and radiation therapy. SPB has a more favorable outlook than MM. Rullo et al. [1] reported a 5-year SPB survival rate of 60% [1]. Due to the likelihood of SPB transforming into MM over time, patients with this lesion should be closely monitored. Two years following the conclusion of radiation, neither clinical nor radiological indicators of recurrence of the lesion were detected in the current patient. Given that the average survival rate for MM is just four years, the disease is essentially incurable and the treatments given to patients are palliative [2], the relevance of SPB case follow-up becomes apparent. The suggested radiation regimen for SPB is 50-40 cGy, which can achieve local control of the lesion of up to 80% [2]. The patient's radiation dose fell within the upper limits of the recommended dose range.
During a 2-year follow-up, neither recurrence nor conversion to MM was found in this patient. Kanazawa et al. [4] stated that there is no assurance regarding the association between SPB and MM. The patient with SPB reported by Matsumura et al. [5] was also symptom-free throughout their 1-year follow-up, but they indicated that additional follow-ups are required to confirm the absence of MM in these individuals. In their examination of records of SBP of the jaws, Agostini et al. [6] claimed that only 50 cases of SP of the jaw had been documented over a period of about 60 years , and in half of these cases, SP progressed into MM, worsening the prognosis. The authors affirm that they have obtained all necessary consent forms from patients.

Conclusion
SPB is rare in the mandible. In a 2-year follow-up, there were no indications of malignancy in the described case.
The diagnosis of mandibular or maxillary SPB necessitates long-term patient monitoring. Moreover, in the differential diagnosis of radionuclides of the mandible, they should always consider unusual entities such as SPB. There is very little information in the literature regarding the CBCT findings of SPB, and one of the objectives of this case report was to characterize such findings. On CBCT, a solitary, elliptical, unilocular, well-defined (but without a sclerotic rim), osteolytic mass which destroys bone cortex is suggestive of SPB.